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Nitazoxanide 500 mg can start working pretty swiftly, but the exact time it takes can vary. For some folks, it kicks in within a day or two, especially for treating certain types of infections like diarrhea caused by parasites. However, for other infections or conditions, it might take a bit longer to see noticeable improvement. Your doctor can give you a better idea based on what you're using nitazoxanide for. Just make sure to take it as prescribed and finish the full course of treatment, even if you start feeling better. That helps ensure the infection is fully knocked out and reduces the chances of it coming back. If you have any concerns or don't see improvement within a reasonable time, it's always best to check back with your healthcare provider.